Warehouse and fulfillment networks form the backbone of global commerce by enabling inventory storage, last-mile delivery, demand forecasting, and real-time logistics synchronization. As cross-border trade scales due to e-commerce, global retailers must manage geographically distributed fulfillment networks that vary by infrastructure maturity, labor systems, automation levels, regulatory limitations, and cost structures. This research compares warehouse network strategies across continents using supply chain design theory, logistics network optimization, and international trade constraints. We introduce the Continental Fulfillment Network Framework (CFNF) to examine how geography, technology, market density, and policy shape fulfillment strategies. This analysis highlights contrasting models: automation-driven fulfillment in North America, port-centric hubs in Europe, manufacturing-integrated warehousing in Asia, and hybrid multimodal networks in emerging continents.