Visual semiotics examines how signs—such as symbols, colors, typography, gestures, and imagery—communicate meaning. However, visual interpretation is culturally conditioned: the same symbol may evoke opposite meanings across nations due to historical narratives, religion, language, collective memory, and aesthetic norms. This study synthesizes semiotic theory, cultural anthropology, and cross-cultural marketing research to analyze how visual meaning varies across nations. The paper introduces the Cross-National Semiotic Interpretation Model (CNSIM) to map how cultural frames mediate perception of signs. Findings highlight that brands adopting standardized global visuals risk misinterpretation, whereas contextual semiotic localization enhances emotional connection and cultural compliance.