Neuro-marketing applies cognitive and neuroscientific methods to analyze and influence consumer responses to marketing stimuli. In digital advertising, these techniques use biometric feedback, AI-driven emotion tracking, and behavioral analytics to optimize engagement. However, cultural variations in cognitive response patterns make global neuro-marketing complex, as emotional triggers that work in one region may fail or backfire in another. This study examines neuro-marketing strategies across international digital advertising environments, using surveys of practitioners, cross-cultural neuromarketing case studies, and UX data from global ad platforms. Results indicate that emotional triggers, attention cues, and persuasive appeals differ across cultural groups. The study proposes a culture-responsive neuro-marketing framework to support ethical global ad design.