Corporate Social Responsibility (CSR) campaigns serve as strategic communication tools that shape public perception of a firm’s ethics, sustainability values, and societal commitments. As brands expand globally, CSR messaging must adapt to diverse cultural priorities, regulatory environments, stakeholder expectations, and media ecosystems. This paper synthesizes literature from cross-cultural marketing, sustainability communication, corporate ethics, and digital activism to examine how CSR campaign messages are constructed and interpreted across global markets. The Global CSR Messaging Alignment Framework (G-CSRMAF) is proposed, highlighting five interconnected dimensions: Cultural Value Framing, Issue Relevance, Communication Channel Strategy, Transparency & Evidence Claims, and Emotional vs. Rational Appeals. Case comparisons include campaigns from Unilever, Patagonia, Coca-Cola, Samsung, Tata, and IKEA. The study offers insights for designing culturally resonant, credible CSR narratives.