Gamification has emerged as a strategic tool in e-commerce to enhance engagement, increase retention, and drive purchasing behavior. When applied across transnational markets, gamification must adapt to different cultural expectations, regulatory standards, platform ecosystems, and motivational triggers. This paper synthesizes behavioral economics, cultural psychology, digital experience design, and global marketing literature to propose the Transnational Gamified Commerce Framework (TGCF). The framework identifies five cross-border determinants: Cultural Motivation Drivers, Platform Ecosystem Maturity, Reward System Localization, Regulatory Contexts, and Socio-Economic Participation Constraints. Case studies include global platforms such as Shopee, Amazon, TikTok Shop, Alibaba, and Mercado Libre. The study highlights design challenges and strategic pathways for global brands deploying gamification across culturally diverse digital markets.