Humor is a widely used persuasive strategy in advertising, yet its effect varies significantly across cultures due to linguistic structure, social norms, values, emotional expression, and contextual interpretation. What is humorous in one culture may be offensive, meaningless, or misunderstood in another. This paper explores humor typologies, cultural dimensions influencing comedic perception, brand communication strategies, and cross-regional case comparisons. Hypothetical survey data from the United States, Japan, India, Germany, and Saudi Arabia reveal that cultural power distance, individualism, and gender norms strongly shape humor preferences. The study proposes a model for designing culturally adaptive humor-based campaigns that balance global brand identity with local sensitivities.1