Influencer–brand partnerships have become a dominant marketing tool in global markets, yet cultural differences significantly shape the effectiveness of influencer messaging, trust formation, audience engagement, brand perception, and conversion behaviors. This research integrates cultural psychology, influencer marketing theory, and international branding to develop the Cross-Cultural Influencer Partnership Framework (CCIPF). Findings reveal that influencers serve diverse cultural functions—from authenticity agents in Western societies to status validators in East Asia and community mobilizers in emerging markets. The paper concludes with strategic implications for global brands seeking culturally aligned influencer collaborations.