Global advertising strategies rely heavily on how consumers process visual, linguistic, and symbolic cues across cultural contexts. Cognitive responses to global advertisements vary due to cultural schemas, language interpretation, memory encoding, media exposure, and emotional triggers. This research synthesizes existing findings in cognitive psychology, marketing communication, cross-cultural theory, and neuromarketing to propose the Global Advertising Cognitive Processing Framework (GACPF). The model includes five stages of processing—Perceptual Attention, Cognitive Appraisal, Cultural Encoding, Memory Consolidation, and Behavioral Response. This framework enhances understanding of how global audiences interpret messaging, symbolism, and brand associations differently across cultural ecosystems. The study highlights implications for advertisers, multinational brands, and academic researchers.